Rbm38 hif1
WebDec 15, 2014 · But too much p53 suppresses cell-cycle progression, causing cell death, premature aging and even cancer." The relationship between p53 and Rbm38 can best be described as a loop: p53 regulates ... WebNov 16, 2014 · HIF1 belongs to a subfamily of the basic-helix-loop-helix-PAS transcription factors . In response to high levels of oxygen, HIF1α protein is modified by prolyl …
Rbm38 hif1
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WebDec 15, 2014 · In this study, Rbm38- and p53-deficient mice models were used to characterize the biological function of Rbm38 and the role of the p53-Rbm38 loop in aging and tumor suppression. We showed that Rbm38 plays an instrumental role in aging, normal hematopoiesis, and tumor suppression. WebThe RNA Binding Protein RBM38 (RNPC1) Regulates Splicing during Late Erythroid Differentiation Laurie A. Heinicke1¤a, Behnam Nabet2¤b, Shihao Shen3,4, Peng Jiang3¤c, Sebastiaan van Zalen1, Benjamin Cieply1, J. Eric Russell1,5, Yi Xing3,4, Russ P. Carstens2,6* 1 Department of Medicine (Hematology-Oncology Division), Perelman School of Medicine, …
WebMar 9, 2024 · RNA binding Motif protein-38 regulates myocardial hypertrophy in LXR-alpha-dependent lipogenesis pathway. [RBM38 Mediates the Proliferation of Acute Myeloid Leukemia Cells HL-60 by Regulating FZD1 mRNA Stability]. RNA-binding protein RBM38 inhibits colorectal cancer progression by partly and competitively binding to PTEN 3'UTR …
WebFunction of RBM38 in human cancer phenotypes a Under hypoxia of lung cancer cells in vitro, HIFα and RBM38 are induced and the former upregulates SIRT1 to inhibits tumor … WebApr 1, 2024 · Interestingly, RBM38 is unique in that it can either suppress or enhance p53 mRNA translation via altered interaction with eIF4E potentially mediated by serine-195 (S195) in RBM38. Thus, multiple RBM38/eIF4E knock-in (KI) cell lines were generated to investigate the significance of eIF4E-RBM38 interaction in controlling p53 activity.
WebAug 17, 2012 · RBM38 was shown to be necessary for proper p53 function, ... may be resistant to hypoxia not only because of decreased apoptosis and senescence but also because of increased HIF1 signalling, ...
WebFeb 15, 2024 · Rbm38 is a p53 target and an RNA-binding protein known to suppress p53 translation by preventing eukaryotic translation initiation factor 4E (eIF4E) from binding to p53 mRNA. In this study, we show that synthetic peptides corresponding to the binding interface between Rbm38 and eIF4E, including an 8 amino acid peptide (Pep8) derived … green family tree genealogyWebScienceDirect.com Science, health and medical journals, full text ... green family used carsWebfrom publication: Hypoxia-inducible factor 1 alpha is regulated by RBM38, a RNAbinding protein and a p53 family target, ... (HIF1), a heterodimeric transcription factor, ... green family texas hobby lobby net worthWebfactor family are targeted by Rbm38, either through RNA stability or RNA translation. Among these family members, Rbm38 stabilizes mRNAs of p21 and p73, while it destabilizes p63 mRNA [9, 11, 22]. Interestingly, phosphorylation of Rbm38 by glycogen synthase kinase 3 (GSK3) converts Rbm38 from a translational repressor to an activator [24 ... green family trustWebMar 21, 2024 · RBM38 (RNA Binding Motif Protein 38) is a Protein Coding gene. Diseases associated with RBM38 include Lung Cancer and Erythema Infectiosum . Gene Ontology … green family trust nzWebApr 17, 2024 · Increased expression of the HIF1 targets Adm, Vegf, Glut1, Pdk1, and Egl-9 family hypoxia-inducible factor 1 (Egln1) in rod ΔVhl and rod ΔVhl;Hif2a mice verified that HIF1 was transcriptionally ... fluke 566 thermometerWebFeb 15, 2024 · The p63 transcription factor, a p53 family protein, regulates genes involved in various cellular processes, including cell growth and differentiation. We previously showed that RNA-binding motif protein (Rbm38) is a p63 target and, in turn, regulates p63α mRNA stability by binding to the AU/U-rich e … fluke 568 thermometer