Irf7 bone
WebIRF7 is a lymphoid-specific factor, which is constitutively expressed in the cytoplasm in B cells, pDCs and monocytes in the spleen, thymus, and peripheral blood lymphocytes, and … WebMar 30, 2005 · Using mice deficient in the Irf7 gene ( Irf7-/- mice), we show that the transcription factor IRF-7 is essential for the induction of IFN-α/β genes via the virus-activated, MyD88-independent...
Irf7 bone
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WebMar 15, 2024 · The bone marrow is the site of haematopoiesis, a highly important bodily process. We believe that our healthy bone marrow atlas is a valuable reference for studying bone marrow processes and bone marrow-related diseases. ... Here our atlas illustrates the different developmental pathways of pDCs (marked by IRF7), namely myeloid and … WebJul 26, 2010 · IRF7 stability was increased in bone marrow-derived macrophages from Ro52-deficient mice stimulated with imiquimod or CpG-B, consistent with a role for Ro52 in the negative regulation of IRF7 signalling. Taken together, these results suggest that Ro52-mediated ubiquitination promotes the degradation of IRF7 following TLR7 and TLR9 …
WebWe confirmed the clinical relevance of these findings in over 800 patients in which high expression of Irf7-regulated genes in primary tumors was associated with prolonged … WebThe purpose of this study was to identify the role of interferon regulatory factor 7 (IRF7) in the bone metastasis of prostate cancer. Herein, we demonstrated the lower expression of IRF7 in...
WebOct 11, 2016 · By using publicly available gene expression datasets, the IRF7 signature was confirmed to be significantly associated with bone metastases-free survival, with low expression of the IRF7 gene set being associated with a higher number of bone metastatic events8. These limited reports demonstrated that the IRF7 gene was a cancer suppressor … WebJun 20, 2011 · Irf7 is a major regulator of the type I IFN pathway9 and was itself suppressed in tumor cells from bone metastases (Supplementary Table 3). We validated the …
WebBackgroundTS-1 is an oral anticancer drug containing a 5-fluorouracil derivative (Tegafur) that is widely used in Japan for the treatment of cancer, especially gastrointestinal tumors. Frequently, ho
WebJul 22, 2024 · Distinct IRF7-associated asthma risk immunophenotypes have dichotomous responses to virus/allergen coexposure and respond differentially to OM-85 pretreatment. Extrapolating to humans, our findings suggest that the beneficial effects OM-85 pretreatment may preferentially target those in high-risk subgroups. Introduction billy the kid show castWebMay 4, 2015 · HGNC Approved Gene Symbol: IRF7 Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:612,555-615,950(from NCBI) Gene-Phenotype Relationships Location Phenotype cynthia frost portland oregonWebOct 11, 2016 · The purpose of this study was to identify the role of interferon regulatory factor 7 (IRF7) in the bone metastasis of prostate cancer. Herein, we demonstrated the lower expression of IRF7 in... billy the kids restaurant little riverWebApr 14, 2024 · The underlying mechanism may be relevant to the increasing expression of IFN-β induced by IRF7, as the downregulation of which could inversely inhibit the activity of NK cells. In conclusion, our findings indicate that IRF7 plays a role in reducing bone metastasis of prostate cancer by IFN-β-mediated NK activity. MeSH terms Animals cynthia from the rugratsWebSilencing of IRF7 pathways in breast cancer cells could facilitate bone metastasis through immune escape. 30 Bidwell et al suggested that IRF7 was the master regulator of type-I interferon-dependent immune responses. 30 Moreover, Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer. 31 cynthia frye bozeman mtWebIRF7 is required for the production and amplification of the antiviral type I (IFN-α/β) and III (IFN-λ) IFNs. The patient's fibroblasts displayed impaired IFN-β and IFN-λ1 production in response to various stimuli, including IAV. billy the kid steppIRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes. Constitutive expression of IRF7 is largely restricted to lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. Multiple IRF7 tra… billy the kids season 2