WebNov 1, 2024 · Silencing STAT3 is confirmed as a promising therapeutic strategy for triple-negative breast cancer (TNBC) therapy to address the issue of its poor prognosis. In this study, the natural product... WebMay 11, 2024 · Cryptotanshinone suppresses the proliferation and induces the apoptosis of pancreatic cancer cells via the STAT3 signaling pathway. Mol Med Rep 2015; 12 : 7782–7788. Article CAS Google Scholar
Cryptotanshinone inhibits proliferation yet induces apoptosis by ...
WebCryptotanshinone (CTS), extracted from the root of Salvia miltiorrhiza Bunge, has a prominent anticancer action through inhibiting activation of STAT3 (Lu et al., 2024). From: New Look to Phytomedicine, 2024 View all Topics Add to Mendeley Download as PDF About this page Pharmacological Advances in Natural Product Drug Discovery Xiaoying Wang, ... WebOct 5, 2024 · Cryptotanshinone inhibited STAT3 activation in myotubes and cachectic muscles. (A) Western blot analysis of myotubes treated with TCM for 0-240 min with the indicated antibodies. (B) Myotubes were pretreated with CTS for 2 h and then stimulated with TCM for 15 min. The level of p-STAT3 (Tyr705) was determined by western blotting … citibank card services phone number
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WebNov 1, 2007 · Abstract. A293 Purpose: STAT3 (Signal transducers and activator of transcription 3) is the transcription factor which is constitutively activated by Janus kinase (JAK) activation and mediates intracellular signaling from cytokines, growth factors, and hormones. It was reported that STAT3 is overexpressed in most of human solid tumors … WebDec 31, 2008 · Cryptotanshinone was colocalized with STAT3 molecules in the cytoplasm and inhibited the formation of STAT3 dimers. Computational modeling showed that … WebAug 29, 2024 · DR5 and STAT3 faults reduce the value to almost half. The STAT3 inhibitor SH5-07 is unable to counter these faults. Cryptotanshinone though not able to regain the fault-free value of apoptosis, is effective in increasing apoptosis despite the … dianne pait whiteville nc